Syntide 2, CaMKII Substrate

Product Number: 105-77

$80
$293

CAS Number: 108334-68-5
Molecular Weight: 1506.92
Salt Form: Acetate
Purity: >96%
Sequence (3-letter): Pro-Leu-Ala-Arg-Thr-Leu-Ser-Val-Ala-Gly-Leu-Pro-Gly-Lys-Lys-OH
Sequence (1-letter): PLARTLSVAGLPGKK-OH
Storage: -20 °C or below
Solubility: Soluble in water (1 mg/ml)

Syntide 2 is a synthetic peptide recognized as a substrate by Ca²⁺ calmodulin-dependent protein kinase II and Ca²⁺ phospholipid-dependent protein kinase (PKC). The sequence is homologous to phosphorylation site 2 on glycogen synthase. Syntide 2 has been used as a probe to assay localization of CaMKII activity and to study the effects of point mutations on phosphorylation activity.

References

1. Enslen, H. et al. (1994) “Characterization of Ca2+/calmodulin-dependent protein kinase IV. Role in transcriptional regulation” J. Biol. Chem. 269: 15520-15527.
2. Yamazaki, T. et al. (1996) “Endothelin-1 Is Involved in Mechanical Stress-induced Cardiomyocyte Hypertrophy” J. Biol. Chem. 271: 3221-3228.

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