Z-Asp-Glu-Val-Asp-AFC (Caspase 3 (Apopain) Substrate)

Product Number: 863-18

$166
$632

CAS Number: 219138-06-4
Molecular Weight: 821.24
Salt Form: N/A
Purity: >96%
Sequence (3-letter): Z-Asp-Glu-Val-Asp-AFC
Sequence (1-letter): Z-DEVD-AFC
Storage: -20 °C or below

Z-Asp-Glu-Val-Asp-AFC is a fluorogenic substrate for caspase 3. Caspase 3 is a cysteine protease that is rapidly activated during apoptosis and cleaves several substrates, including poly(ADP-ribose) polymerase (PARP). Caspase 3 is activated by Caspases 8, 9 and 10 and cleaves and activates caspase 6 and 7. Caspase 3 cleaves the amyloid precursor protein (APP) contributing to Amyloid beta formation and has been implicated in Alzheimer’s disease and proposed as a target for drug discovery.

Activity is quantified by release of free fluorescent 7-amino-4-trifluoromethylcoumarin (AFC) which excites at 395-400 nm and emits at 495-505 nm.

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Caspase, Enzyme Substrates

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-20 °C or below

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