Z-Asp-Glu-Val-Asp-AFC (Caspase 3 (Apopain) Substrate)

Product Number: 863-18

$150.00$573.00

$150.00
$573.00
SKU: 863-18 Category: Tags: ,

CAS Number: 219138-06-4
Molecular Weight: 821.24
Salt Form: N/A
Purity: >96%
Sequence (3-letter): Z-Asp-Glu-Val-Asp-AFC
Sequence (1-letter): Z-DEVD-AFC
Storage: -20 °C or below

Z-Asp-Glu-Val-Asp-AFC is a fluorogenic substrate for caspase 3. Caspase 3 is a cysteine protease that is rapidly activated during apoptosis and cleaves several substrates, including poly(ADP-ribose) polymerase (PARP). Caspase 3 is activated by Caspases 8, 9 and 10 and cleaves and activates caspase 6 and 7. Caspase 3 cleaves the amyloid precursor protein (APP) contributing to Amyloid beta formation and has been implicated in Alzheimer’s disease and proposed as a target for drug discovery.

Activity is quantified by release of free fluorescent 7-amino-4-trifluoromethylcoumarin (AFC) which excites at 395-400 nm and emits at 495-505 nm.

We are in the process of migrating our technical data sheets (TDS) to this space. They can currently be found in the description section of the product pages. Thank you for your patience. For any technical questions, please contact us at echelon@echelon-inc.com

 

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