Z-Ala-Ala-Asp-AFC (Cathepsin S Substrate, fluorogenic)

Product Number: 874-06

$190

Molecular Weight: 620.54
Salt Form: N/A
Purity: >96%
Sequence (3-letter): Z-Ala-Ala-Asp-AFC
Sequence (1-letter): (Z)AAD(AFC)
Storage: -20 °C or below

Z-Ala-Ala-Asp-AFC is a fluorogenic substrate for cathepsin S, a lysosomal cysteine protease with important roles in MHC Class II antigen presentation and nociception. Cathepsin S also cleaves several extracellular matrix proteins (laminin, fibronectin elastin, osteocalcin) and glycosaminoglycans (heparin sulfate, chondroitin sulfate).

Activity is quantified by release of free fluorescent 7-amino-4-trifluoromethylcoumarin (AFC) which excites at 395-400 nm and emits at 495-505 nm.

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-20 °C or below

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