YSH-12

Product No: N-1009

$150
$325
$575

YSH-12 is an ionizable lipid used to generate lipid nanoparticles to deliver RNA. LNPs optimized with the formula 15:10:25:2.5 (YHS-12/DOPE/cholesterol/DMG-PEG) delivered mRNA and siRNA together to Raw264.7-Luc cells. YSH-12 LNPs incorporating CRV peptide were able to target monocytes in situ to deliver MRSA-targeted chimeric antigen receptor (CAR) mRNA (SasA-CAR mRNA) and CASP11 siRNA. The engineered monocytes showed increased bactericidal activity in a MRSA-induced mouse model.

 

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Lipids

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Ionizable/Cationic Lipids

CAS Number

2959463-68-2

Molecular Formula

C56H112N4O2

Molecular Weight (g/mol)

873.54

Purity

95%

Storage

-20 °C or below

Shipping Temp

Ambient Temperature

Technical Data Sheet

C. Tang, W. Jing,et al. (2024) “mRNA-Laden Lipid-Nanoparticle-Enabled inSitu CAR-Macrophage Engineering for theEradication of Multidrug-Resistant Bacteria in a Sepsis Mouse Model” ACS Nano 8(3), 2261–2278. DOI: 10.1021/acsnano.3c10109.

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