Unlabeled Shuttle PIP Carrier 2

Unlabeled Shuttle PIP Carrier 2 (Histone H1) has successfully delivered the following phosphoinositides into cells: PtdIns(4,5)P₂, PtdIns(3,4)P₂, PtdIns(3,5)P₂, PtdIns(3,4,5)P₃, and their fluorescent analogs.

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To provide our customers with additional options in designing their own cell-delivery applications, Echelon offers fluorescent and non-fluorescent carriers as stand alone products outside our Shuttle PIP kits. Customers can use the most effective carrier for their system along with the individual fluorescent or non-fluorescent phosphoinositides of their choice.

Provided as 2 x 50 nmoles

Storage

Store dried product at -20 °C. Once reconstituted, store at 2-8 °C. Do not freeze thaw multiple times. Note: phosphate buffers are not recommended and may alter complex formation with phosphoinositides. We do not recommend storing carriers and PIPs together as complexes.

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Publications

1) Maffucci, T., A. Brancaccio, et al. (2003). “Insulin induces phosphatidylinositol-3-phosphate formation through TC10 activation.” Embo J 22(16): 4178-89.
2) Soughayer, J. S., Y. Wang, et al. (2004). “Characterization of TAT-mediated transport of detachable kinase substrates.” Biochemistry 43(26): 8528-40.
3) Im, E., S. H. Rhee, et al. (2010). “Corticotropin-releasing hormone family of peptides regulates intestinal angiogenesis.” Gastroenterology 138(7): 2457-67

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