N-terminal His-tagged, recombinant human SHIP2 (truncated form containing SH2 domain and inositol 5-phophatase catalytic domain)
Storage: Store product > -70 ºC. Enzyme is stable for at least 6 months at -70 ºC as undiluted stock
Specificity: SHIP2 selectively removes the phosphate from the 5’ position of the inositol ring of PtdIns(3,4,5)P3
Molecular Weight: 103 kDa
Specific Activity: request Certificate of Analysis (COA)
This His-tagged, recombinant human SHIP2 (truncated form containing SH2 domain and inositol 5-phophatase catalytic domain) is tested for activity against PIP3 and is purified from E.coli using Ni-NTA column chromatography.
SH2-containing 5`-inositol phosphatase 2 (SHIP2) is a lipid phosphatase which converts PI(3,4,5)P3 to PI(3,4)P2. This negative regulation of insulin signaling has a fundamental impact on insulin resistance. SHIP2 down-regulates insulin signaling and is present at higher levels in diabetes and obesity. Abnormalities in SHIP function are increasingly linked to disease, in particular in the role of SHIP as a negative regulator of cytokine and immune receptor signaling.
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