1-Stearoyl-2-hydroxy-sn-glycero-3-phosphocholine (S-lysoPC, LPC) is generated through hydrolysis of the sn-2 acyl chain of PC by phospholipase A2. It is a major component of oxidized low-density lipoprotein and is believed to have an important role in inflammatory diseases and atherosclerosis. LysoPC is the substrate for Autotaxin/LysoPLD generating lysophosphatidic acid which has an important role in cell motility.
References: Matsumoto, T., Kobayashi, T., Kamata, K. (2007) “Role of lysophosphatidylcholine (LPC) in atherosclerosis”, Curr. Med. Chem. 14, 3209-220.
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