Purified anti-LBPA monoclonal antibody
Subclass: IgG1k (clone 6C4)
Applications: Immunofluorescence, ELISA
Storage: Store at -20 °C for up to 60 days. Aliquot and store at -20 or -70 °C if longer storage is necessary. Avoid repeated freeze/thaw cycles.
The purified Mouse Anti-LBPA antibody recognizes an important but unusual eukaryotic lipid, lysobisphosphatidic acid, (LBPA) also termed bis(monoacylglyceryl)phosphate (BMP). LBPA is found primarily in late endosomes and is a cellular marker of this compartment. Further, LBPA is a lipid antigen for the autoimmune disorder, anti-phospholipid syndrome (APS).
Featured in Publications:
1) Kobayashi, T., M. H. Beuchat, et al. (1999). “Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport.” Nat Cell Biol 1(2): 113-8.
2) Zornetta, I., L. Brandi, et al. (2010). “Imaging the cell entry of the anthrax oedema and lethal toxins with fluorescent protein chimeras.” Cell Microbiol 12(10): 1435-45.
3) Otomo, T., K. Higaki, et al. (2011). “Lysosomal Storage Causes Cellular Dysfunction in Mucolipidosis II Skin Fibroblasts.” J Biol Chem 286(40): 35283-90.