Purified Anti-PtdIns(4,5)P2 IgM

Product Number: Z-P045

$92
$290
$498

Purified Anti-PtdIns(4,5)P2 (2C11) monoclonal antibody.
Subclass: IgM
Source: Mouse
Applications: ELISA, Immunofluorescence, Protein-Lipid Overlay (PIP Strip)
Clonality: Monoclonal , 2C11


Product Background: Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4,5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PIP3.

Storage

2-8 °C for up to 30 days, -20 °C for greater than 30 days. Do not freeze thaw multiple times

Featured in Publications

1) Terebiznik, M. R., O. V. Vieira, et al. (2002). “Elimination of host cell PtdIns(4,5)P(2) by bacterial SigD promotes membrane fission during invasion by Salmonella.” Nat Cell Biol 4(10): 766-73.
2) Hirono, M., C. S. Denis, et al. (2004). “Hair cells require phosphatidylinositol 4,5-bisphosphate for mechanical transduction and adaptation.” Neuron 44(2): 309-20.
3) Leloup, L., H. Shao, et al. (2010). “m-calpain Activation Is Regulated by Its Membrane Localization and by Its Binding to Phosphatidylinositol 4,5-Bisphosphate.” Journal of Biological Chemistry 285(43): 33549-33566.

Product keywords: PIP2, PI(4,5)P2, PtdIns(4,5)P2, IgM, anti-PIP2


Technical Data Sheet

Categories

Antibodies & Proteins

Filter

Antibody, Lipid Binding, PI(4,5)P2

Shipping Temp

Dry Ice

Storage

-20 °C or below

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