Purified Anti-PtdIns(4,5)P2 (2C11) monoclonal antibody.
Subclass: IgM
Source: Mouse
Applications: ELISA, Immunofluorescence, Protein-Lipid Overlay (PIP Strip)
Clonality: Monoclonal , 2C11
Product Background: Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4,5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PIP3.
Storage
2-8 °C for up to 30 days, -20 °C for greater than 30 days. Do not freeze thaw multiple times
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1) Terebiznik, M. R., O. V. Vieira, et al. (2002). “Elimination of host cell PtdIns(4,5)P(2) by bacterial SigD promotes membrane fission during invasion by Salmonella.” Nat Cell Biol 4(10): 766-73.
2) Hirono, M., C. S. Denis, et al. (2004). “Hair cells require phosphatidylinositol 4,5-bisphosphate for mechanical transduction and adaptation.” Neuron 44(2): 309-20.
3) Leloup, L., H. Shao, et al. (2010). “m-calpain Activation Is Regulated by Its Membrane Localization and by Its Binding to Phosphatidylinositol 4,5-Bisphosphate.” Journal of Biological Chemistry 285(43): 33549-33566.
Product keywords: PIP2, PI(4,5)P2, PtdIns(4,5)P2, IgM, anti-PIP2
