PI(3,5)P2 Grip

Product number: G-3501


PI(3,5)P2 Grip (G-3501) is a recombinant N-terminal GST fusion PI(3,5)P2 binding protein expressed in E. Coli. G-3501 has been validated for use in ELISA and as a control for lipid pulldown experiments.

Phosphatidylinositol 3,5-bisphosphate is in very low abundance and is required for retrograde membrane trafficking from lysosomal and late endosomal compartments to the Golgi and is involved in autophagy. PI(3,5)P2 levels are controlled by the 5-kinase PIKfyve and the 5-phosphatase Fig4/Sac3 and disregulation is linked to several human neuropathies (eg Chacot-Marie-Tooth disease).

Storage: -20 °C. Aliquot and freeze if intended for multiple uses. Protein will be stable for at least 6 months from date of shipment.


1. Dove S.K., Piper, R.C., McEwen, R.K., Yu, J.W., King, M.C., Hughes, D.C., Thuring, J., Holmes, A.B., Cooke, F.T., Michell, R.H., Parker, P.J., & Lemmon,
M.A. (2004) Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors. EMBO J. 1-12.

2. Dong X., Shen D., Wang X., Dawson T., Li X., Zhang Q., Cheng X., Zhang Y., Weisman L.S., Delling M. & Xu H. (2010) PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome. Nat Comm 1(38)

Technical Data Sheet


Antibodies & Proteins


Lipid Binding, PI(3,5)P2

You may also like…

  • Purified Anti-PtdIns(3,5)P2 - Echelon Biosciences
    Antibodies & Proteins

    Purified Anti-PtdIns(3,5)P2 IgG

    Product Number: Z-P035

    $458 View products
  • PI(3,5)P2 diC16 9Phosphatidylinositol 3,5-bisphosphate diC16) - Echelon Biosciences

    PI(3,5)P2 diC16

    Product Number: P-3516

    $59$488 View products
  • PI(3,5)P2 PIP Beads - Echelon Biosciences
    Biochemical Reagents

    PI(3,5)P2 Beads

    Product Number: P-B035A

    $147$762 View products
  • PI(3,5)P2 diC8 (Phosphatidylinositol 3,5-bisphosphate diC8) - Echelon Biosciences

    PI(3,5)P2 diC8

    Product Number: P-3508

    $54$453 View products
Shopping Cart
Scroll to Top

Technical Support

Bulk & Custom Orders