PI3-K alpha Inhibitor 2

Product Number: B-0304

$50.00$212.00

$50.00
$212.00

3-(4-Morpholinothieno[3,2-d]pyrimidin-2-yl)phenol is a selective inhibitor for the α-isoform of PI 3-Kinase (IC50: PI 3-Kα = 2 nM, PI 3-Kβ = 16 nM, PI3-Kγ = 660 nM, PI3KC2β = 220 nM)). It showed >1000-fold selectivity vs. protein kinases such as PKA, KDR, PKCa, and E/CDK2 (IC50 = 91, 3.4, 466, 288 μM). It inhibited proliferation of A375 melanoma cells at 580 nM. Also known as PI3-K Inhibitor 2, PIK2.


References

1) M. Hayakawa, et al. “Synthesis and biological evaluation of 4-morpholino-2-phenyl quinazolines and related derivatives as novel PI3 kinase p110a inhibitors” Bioorg. Med. Chem. 2006, 14, 6847-6858.


Categories

Biochemical Reagents

Filter

Inhibitor, PI3K

CAS Number

371943-05-4

Molecular Formula

C16H15N3O2S

Molecular Weight (g/mol)

313.4

Purity

>95%

Storage

4 °C or below

Technical Data Sheet

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