Dnp-Pro-Leu-Gly-Met-Trp-Ser-Arg-OH (MMP-2 / MMP-9 Substrate)

Product Number: 865-10


Molecular Weight: 1011.42
Salt Form: TFA
Purity: >96%
Sequence (3-letter): Dnp-Pro-Leu-Gly-Met-Trp-Ser-Arg-OH
Sequence (1-letter): Dnp-PLGMWSR-OH
Storage: -20 °C or below

Dnp-Pro-Leu-Gly-Met-Trp-Ser-Arg-OH is a fluorogenic substrate for zinc-dependent human matrix metalloproteinases (MMP) 2 & 9. MMP-2 (Fibroblast gelatinase, gelatinase A) is a type IV collagenase  with an important role in breakdown of the extracellular matrix. It has also been implicated in cancer cell invasion and angiogenesis.  MMP-9 (neutrophil gelatinase, gelatinase B) cleaves the alpha 2 chain of type I collagen, collagen types III, IV, V, and gelatins.  MMP-9 is found in human fibrosarcoma cells and produced in human bone osteoclasts and, together with MMP-1 and cysteine proteinases, may be involved in bone collagen degradation.

Activity is measured by excitation at  280nm and emission at 360nm.




Enzyme Substrates

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