Molecular Weight: 1011.42
Salt Form: TFA
Sequence (3-letter): Dnp-Pro-Leu-Gly-Met-Trp-Ser-Arg-OH
Sequence (1-letter): Dnp-PLGMWSR-OH
Storage: -20 °C or below
Dnp-Pro-Leu-Gly-Met-Trp-Ser-Arg-OH is a fluorogenic substrate for zinc-dependent human matrix metalloproteinases (MMP) 2 & 9. MMP-2 (Fibroblast gelatinase, gelatinase A) is a type IV collagenase with an important role in breakdown of the extracellular matrix. It has also been implicated in cancer cell invasion and angiogenesis. MMP-9 (neutrophil gelatinase, gelatinase B) cleaves the alpha 2 chain of type I collagen, collagen types III, IV, V, and gelatins. MMP-9 is found in human fibrosarcoma cells and produced in human bone osteoclasts and, together with MMP-1 and cysteine proteinases, may be involved in bone collagen degradation.
Activity is measured by excitation at 280nm and emission at 360nm.