Dnp-Pro-Leu-Gly-Met-Trp-Ser-Arg-OH (MMP-2 / MMP-9 Substrate)

Product Number: 865-10

$150.00

$150.00
SKU: 865-10 Category: Tag:

Molecular Weight: 1011.42
Salt Form: TFA
Purity: >96%
Sequence (3-letter): Dnp-Pro-Leu-Gly-Met-Trp-Ser-Arg-OH
Sequence (1-letter): Dnp-PLGMWSR-OH
Storage: -20 °C or below

Dnp-Pro-Leu-Gly-Met-Trp-Ser-Arg-OH is a fluorogenic substrate for zinc-dependent human matrix metalloproteinases (MMP) 2 & 9. MMP-2 (Fibroblast gelatinase, gelatinase A) is a type IV collagenase  with an important role in breakdown of the extracellular matrix. It has also been implicated in cancer cell invasion and angiogenesis.  MMP-9 (neutrophil gelatinase, gelatinase B) cleaves the alpha 2 chain of type I collagen, collagen types III, IV, V, and gelatins.  MMP-9 is found in human fibrosarcoma cells and produced in human bone osteoclasts and, together with MMP-1 and cysteine proteinases, may be involved in bone collagen degradation.

Activity is measured by excitation at  280nm and emission at 360nm.

We are in the process of migrating our technical data sheets (TDS) to this space. They can currently be found in the description section of the product pages. Thank you for your patience. For any technical questions, please contact us at echelon@echelon-inc.com

 

Categories

Peptides

Filter

Enzyme Substrates

Shopping Cart
Scroll to Top