MG-115 (Proteasome Inhibitor)

Product Number: 882-10


SKU: 882-10 Category: Tags: , , ,

CAS Number: 133407-86-0
Molecular Weight: 461.29
Salt Form: N/A
Purity: >96%
Sequence (3-letter): Z-Leu-Leu-Nva-CHO
Sequence (1-letter): Z-LL(Nva)-CHO
Storage: -20 °C or below

MG-115 (Z-Leu-Leu-Nva-CHO) is a potent, cell permeable inhibitor of the 20S proteosome. It forms a reversible hemiacetal adduct and can also inhibit cathepsins and calpains. It reduces degradation of ubiquitinated proteins and blocks proteolytic conversion of protein precursors. MG-115 is known to induce the heat shock response and apoptosis.


Rock, K.L., Gramm, C., Rothstein, L., et al. (1994) “Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules”. Cell 78, 761-771.

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