Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(DNP)-OH (Caspase 1 Substrate)

Product Number: 865-21

$166

CAS Number: 189696-01-3
Molecular Weight: 1144.43
Salt Form: N/A
Purity: >96%
Sequence (3-letter): Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(DNP)-OH
Sequence (1-letter): (Mca)YVADAP(Lys(DNP))-OH
Storage: -20 °C or below

Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(DNP)-OH is a FRET substrate for caspase 1. Caspase 1/Interleukin 1b converting enzyme (ICE) is a cysteine protease that preferentially cleaves substrates built on VAD (val-ala-asp) or WEAD (trp-glu-ala-asp) sequences.  ICE converts inactive IL-1 beta precursor to a pro-inflammatory cytokine that mediates a wide range of immune and inflammatory response.  ICE-related cysteine proteases are required for E1A-induced, p53-dependent apoptosis in baby rat kidney (BRK) cells. Adenovirus E1B 19K protein, which is a potent inhibitor of apoptosis, inhibits activation of these proteases in BRK cells.

Activity can be continuously measured by excitation at 325nm and emission at 392 nm

Categories

Peptides

Filter

Enzyme Substrates

Shipping Temp

Ambient Temperature

Storage

-20 °C or below

Shopping Cart
Scroll to Top

Technical Support

Bulk & Custom Orders