Linoleoyl LPA, 18:2 LPA

Product Number: L-0182

$78
$566

Linoleoyl LPA, 18:2 LPA is an LPA analog with an unsaturated acyl chain. Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation, chemotaxis, platelet aggregation, wound healing, angiogenesis, tumor invasion, and smooth muscle contraction. LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer, LPA primarily promotes cell survival, migration and invasion. May contain up to 5-10% of the 2-acyl isomer due to acyl transfer.

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Lipids

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Lysophosphatidic Acid, Lysophospholipid

CAS Number

65528-85-0

Molecular Formula

C21H38NaO7P

Molecular Weight (g/mol)

456.49

Purity

>95%

Storage

-20 °C or below

Shipping Temp

Gel Ice

Technical Data Sheet

1) Huang, L. S., et al. (2007). “Linoleoyl lysophosphatidic acid and linoleoyl lysophosphatidylcholine are efficient substrates for mammalian lipoxygenases.” Biochim Biophys Acta 1770(7): 1062-1070.
2) Yanagida, K., et al. (2009). “Identification and Characterization of a Novel Lysophosphatidic Acid Receptor, p2y5/LPA6.” Journal of Biological Chemistry 284(26): 17731-17741.
3) Morales-Lazaro, S. L., et al. (2014). “Structural Determinants of the Transient Receptor Potential 1 (TRPV1) Channel Activation by Phospholipid Analogs.” J. Biol. Chem. 289(35): 24079-24090.
4) Reinartz, S., et al. (2019). “Cell-type-selective pathways and clinical associations of lysophosphatidic acid biosynthesis and signaling in the ovarian cancer microenvironment.” Molecular Oncology 13(2): 185-201.
5) Nathan, S., et al. (2021). “CREB-dependent LPA-induced signaling initiates a pro-fibrotic feedback loop between small airway basal cells and fibroblasts.” Respiratory Research 22(1): 97.
6) Suenaga, R., et al. (2022). “Lateral access mechanism of LPA receptor probed by molecular dynamics simulation.” PLoS ONE 17(2): e0263296.

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