Linoleoyl LPA, 18:2 LPA is an LPA analog with an unsaturated acyl chain. Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation, chemotaxis, platelet aggregation, wound healing, angiogenesis, tumor invasion, and smooth muscle contraction. LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer, LPA primarily promotes cell survival, migration and invasion. May contain up to 5-10% of the 2-acyl isomer due to acyl transfer.
Linoleoyl LPA, 18:2 LPA
Product Number: L-0182
$71.00 – $513.00
Lysophosphatidic Acid, Lysophospholipid
|Molecular Weight (g/mol)||
-20 °C or below
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2) Yanagida, K., et al. (2009). “Identification and Characterization of a Novel Lysophosphatidic Acid Receptor, p2y5/LPA6.” Journal of Biological Chemistry 284(26): 17731-17741.
3) Morales-Lazaro, S. L., et al. (2014). “Structural Determinants of the Transient Receptor Potential 1 (TRPV1) Channel Activation by Phospholipid Analogs.” J. Biol. Chem. 289(35): 24079-24090.
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5) Nathan, S., et al. (2021). “CREB-dependent LPA-induced signaling initiates a pro-fibrotic feedback loop between small airway basal cells and fibroblasts.” Respiratory Research 22(1): 97.
6) Suenaga, R., et al. (2022). “Lateral access mechanism of LPA receptor probed by molecular dynamics simulation.” PLoS ONE 17(2): e0263296.