Linoleoyl LPA, 18:2 LPA

Product Number: L-0182

$71.00$513.00

$71.00
$513.00
SKU: L-0182- Category: Tags: , , ,

Linoleoyl LPA, 18:2 LPA is an LPA analog with an unsaturated acyl chain. Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation, chemotaxis, platelet aggregation, wound healing, angiogenesis, tumor invasion, and smooth muscle contraction. LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer, LPA primarily promotes cell survival, migration and invasion. May contain up to 5-10% of the 2-acyl isomer due to acyl transfer.

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Lipids

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Lysophosphatidic Acid, Lysophospholipid

CAS Number

65528-85-0

Molecular Formula

C21H38NaO7P

Molecular Weight (g/mol)

456.49

Purity

>95%

Storage

-20 °C or below

Technical Data Sheet

1) Huang, L. S., et al. (2007). “Linoleoyl lysophosphatidic acid and linoleoyl lysophosphatidylcholine are efficient substrates for mammalian lipoxygenases.” Biochim Biophys Acta 1770(7): 1062-1070.
2) Yanagida, K., et al. (2009). “Identification and Characterization of a Novel Lysophosphatidic Acid Receptor, p2y5/LPA6.” Journal of Biological Chemistry 284(26): 17731-17741.
3) Morales-Lazaro, S. L., et al. (2014). “Structural Determinants of the Transient Receptor Potential 1 (TRPV1) Channel Activation by Phospholipid Analogs.” J. Biol. Chem. 289(35): 24079-24090.
4) Reinartz, S., et al. (2019). “Cell-type-selective pathways and clinical associations of lysophosphatidic acid biosynthesis and signaling in the ovarian cancer microenvironment.” Molecular Oncology 13(2): 185-201.
5) Nathan, S., et al. (2021). “CREB-dependent LPA-induced signaling initiates a pro-fibrotic feedback loop between small airway basal cells and fibroblasts.” Respiratory Research 22(1): 97.
6) Suenaga, R., et al. (2022). “Lateral access mechanism of LPA receptor probed by molecular dynamics simulation.” PLoS ONE 17(2): e0263296.

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