Linoleoyl LPA, 18:2 LPA is an LPA analog with an unsaturated acyl chain. Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation, chemotaxis, platelet aggregation, wound healing, angiogenesis, tumor invasion, and smooth muscle contraction. LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer, LPA primarily promotes cell survival, migration and invasion. May contain up to 5-10% of the 2-acyl isomer due to acyl transfer.
| Categories | Lipids |
|---|---|
| Filter | Lysophosphatidic Acid, Lysophospholipid |
| CAS Number | 65528-85-0 |
| Molecular Formula | C21H38NaO7P |
| Molecular Weight (g/mol) | 456.49 |
| Purity | >95% |
| Storage | -20 °C or below |
1) Huang, L. S., et al. (2007). “Linoleoyl lysophosphatidic acid and linoleoyl lysophosphatidylcholine are efficient substrates for mammalian lipoxygenases.” Biochim Biophys Acta 1770(7): 1062-1070.
2) Yanagida, K., et al. (2009). “Identification and Characterization of a Novel Lysophosphatidic Acid Receptor, p2y5/LPA6.” Journal of Biological Chemistry 284(26): 17731-17741.
3) Morales-Lazaro, S. L., et al. (2014). “Structural Determinants of the Transient Receptor Potential 1 (TRPV1) Channel Activation by Phospholipid Analogs.” J. Biol. Chem. 289(35): 24079-24090.
4) Reinartz, S., et al. (2019). “Cell-type-selective pathways and clinical associations of lysophosphatidic acid biosynthesis and signaling in the ovarian cancer microenvironment.” Molecular Oncology 13(2): 185-201.
5) Nathan, S., et al. (2021). “CREB-dependent LPA-induced signaling initiates a pro-fibrotic feedback loop between small airway basal cells and fibroblasts.” Respiratory Research 22(1): 97.
6) Suenaga, R., et al. (2022). “Lateral access mechanism of LPA receptor probed by molecular dynamics simulation.” PLoS ONE 17(2): e0263296.
