Inositol phosphates are important signaling molecules involved in numerous cellular functions. Inositol 1,3-bisphosphate (Ins(1,3)P2) is an intermediate in the inositol phosphate pathway, being produced by dephosphorylation of Ins (1,3,4)P3 by type II inositol 1,3,4 trisphosphate 4-phosphatase.
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| Categories | Lipids |
|---|---|
| Filter | Inositol Phosphate |
| CAS Number | 214332-52-2 |
| Molecular Formula | C6H12Na2O12P2 |
| Molecular Weight (g/mol) | 384.07 |
| Purity | >95% |
| Storage | -20 °C or below |
1) Taylor, G. S., et al. (2000). “Inaugural article: myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate.” Proc Natl Acad Sci U S A 97(16): 8910-8915.
2) Sankaran, V. G., et al. (2001). “High-affinity binding of a fyve domain to phosphatidylinositol 3- phosphate requires intact phospholipid but not fyve domain oligomerization.” Biochemistry 40(29): 8581-8587.
3) Kim, S. A., et al. (2002). “Myotubularin and MTMR2, phosphatidylinositol 3-phosphatases mutated in myotubular myopathy and type 4B Charcot-Marie-Tooth disease.” J Biol Chem 277(6): 4526-4531.
4) Wawra, S., et al. (2012). “The avirulence protein 3a (AVR3a) from the potato pathogen Phytophthora infestans, forms homodimers through its predicted translocation region and does not specifically bind phospholipids.” Journal of Biological Chemistry 287(45): 38101-38109.
