GroPI(4)P

Product Number: P-4000

Glycerophosphoinositol 4-phosphate (GroPI(4)P) - Echelon Biosciences

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Glycerophosphoinositol 4-phosphate (GroPI(4)P) is a synthetic, purified PI(4)P without acyl chains at the 1- and 2-positions of the glycerol.

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4-phosphate (PI(4)P) is the biosynthetic precursor to PI(4,5)P2 and has an important roles in regulating sphingomyelin and glycosphingolipid metabolism and membrane trafficking at the exit of the Golgi complex.

Bulk discounts available, please email echelon@echelon-inc.com for information.

Categories	Lipids
Filter	Glycerolphosphoinositide, Phosphoinositides
CAS Number	129830-96-2
Molecular Formula	C9H17Na3O14P2
Molecular Weight (g/mol)	480.10
Purity	>95%
Storage	-20 °C or below

Technical Data Sheet

1) Zizza, P., C. Iurisci, et al. (2012). “Phospholipase A2 IValpha regulates phagocytosis independent of its enzymatic activity.” J Biol Chem 287(20): 16849-16859.
2) Vessichelli, M., et al. (2017). “The natural phosphoinositide derivative glycerophosphoinositol inhibits the lipopolysaccharide-induced inflammatory and thrombotic responses.” Journal of Biological Chemistry 292(31): 12828-12841.
3) Varone, A., et al. (2019). “A signalling cascade involving receptor-activated phospholipase A2, glycerophosphoinositol 4-phosphate, Shp1 and Src in the activation of cell motility.” Cell Communication and Signaling 17(1): 20.

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