ET Receptor Antagonist (PD 145065)

Product Number: 331-18

$123.00$444.00

$123.00
$444.00

CAS Number: 153049-49-1
Molecular Weight: 950.15
Salt Form: Na+
Purity: >96%
Sequence (3-letter): Ac-D-Bhg-Leu-Asp-Ile-Ile-Trp-OH
Sequence (1-letter): Ac-(D-Bhg)LDIIW-OH
Storage: -20 °C or below
Solubility: water, PBS and DMSO 1 mg/ml

D-Bhg = D-5H-Dibenzo[a,d]cycloheptene-5-acetic acid

ET Antagonist PD 145065 is used as an endothelin-A/endothelin-B (ETA/ETB) receptor antagonist. PD 145065 is also a growth factor that binds to G protein-coupled receptors and serves as a useful model to study mitogenic signal transduction by vasoactive peptides.

References

1. Kanagy, N.L. et al. (2001) “Role of Endothelin in Intermittent Hypoxia-Induced Hypertension” 37 (2 Pt 2): 511-5.
2. Bourque, S.L. et al (2012) “Role of endothelin-1 in the hyper-responsiveness to nitrovasodilators following acute NOS inhibition” Br. J. Pharmacol. 165 (6): 1992-1999.
3. Dobrowolski, L. (2003) “Cardiovascular and renal effects of endothelin receptor blockade with PD 145065 and interaction with urodilatin” Acta Physiol. Scand. 159 (1): 7-13.

We are in the process of migrating our technical data sheets (TDS) to this space. They can currently be found in the description section of the product pages. Thank you for your patience. For any technical questions, please contact us at echelon@echelon-inc.com

 

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Peptides

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Cardiovascular, Neuropeptides & Hormones

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