GloPIPs Biotin-PI(4,5)P2

Product Number: C-45B6a

$140.00$572.00

$140.00
$572.00

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4,5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PI(3,4,5)P3.


GloPIPs are labeled at the sn-1 position with BODIPY®-FL (505/513), BODIPY®-TMR (544/574), or biotin. The sn-1 linkage in these labeled PIPs has been changed to a more stable amide from an ester. Results from experiments conducted at Echelon indicated that this minor chemical change did not have a significant effect in any of the applications tested.

Storage

-20°C

Featured in Publications

1) Goksoy, E., Y.-Q. Ma, et al. (2008). “Structural Basis for the Autoinhibition of Talin in Regulating Integrin Activation.” Molecular cell 31(1): 124.
2) Michailidis, I., R. Rusinova, et al. (2011). “Phosphatidylinositol-4,5-bisphosphate regulates epidermal growth factor receptor activation.” Pflugers Archiv European Journal of Physiology 461(3): 387-397


Categories

Lipids

Filter

Biotinylated, Phosphoinositides, PI(4,5)P2

Technical Data Sheet

Scroll to Top