BODIPY TMR PI(4,5)P2

Product Number: C-45M6

$478
$822

BODIPY TMR PI(4,5)P2 (BODIPY TMR Phosphatidylinositol 4,5-bisphosphate) is a water soluble analog of PI(4,5)P2 (PIP2) labeled with the orange fluorophore, Bodipy®-TMR, at the sn-1 position.


Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4,5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PI(3,4,5)P3.

Bulk discounts available, please email echelon@echelon-inc.com for information.

Categories

Lipids

Filter

Fluorescent, Phosphoinositides, PI(4,5)P2

Excitation/Emission

542/574 nm

Molecular Formula

C78H147BF2N9O22P3

Molecular Weight (g/mol)

1,704.78

Purity

>95%

Storage

-20 °C or below, protect from light

Shipping Temp

Dry ice or gel ice depending on destination

Technical Data Sheet

1) Cabanos C, Wang M, Han X, Hansen SB (2017) A Soluble Fluorescent Binding Assay Reveals PIP2 Antagonism of TREK-1 Channels. Cell Rep 20(6):1287–1294
2) Bethoney, K. A., et al. (2009). “A possible effector role for the pleckstrin homology (PH) domain of dynamin.” Proc Natl Acad Sci U S A 106(32): 13359-13364.
3) Schäfer, J., et al. (2020). “Leaflet-dependent distribution of PtdIns[4,5]P2 in supported model membranes.” Langmuir 35(5): 1320-1328.
4) Janetzko, J., et al. (2022). “Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics.” Cell 185(24): 4560-4573.e4519.

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