Gamma Secretase Inhibitor

Product Number: 649-27


CAS Number: 133407-83-7
Molecular Weight: 475.3
Salt Form: N/A
Purity: >95%
Sequence (3-letter): Z-Leu-Leu-Nle-CHO
Sequence (1-letter): Z-LL(Nle)-CHO
Storage: -20 °C or below
Solubility: DMSO > 1 mg/mL

Gamma Secretase Inhibitor, sequence Z-Leu-Leu-Nle-CHO (Z-Leu-Leu-Nle-al), is a leupeptin analog which inhibits gamma secretase. Gamma secretase is a membrane associated protein complex consisting of presenilin, nicastrin, Aph-1, and Pen-2. It catalyzes the cleavage of Notch and Beta Amyloid proteins and is implicated in Alzheimer’s disease.




Central Nervous System, Inhibitor

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Ambient Temperature


-20 °C or below

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