Farnesoic acid ((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienoic acid) is the substrate of farnesoic acid O-methyltransferase which produces the crustacean reproductive hormone, methyl farnesoate (MF). MF is responsible for enhancing reproductive maturation, maintaining juvenile morphology, and influencing male sex determination. Farnesoic acid also inhibits filiment formation in C. albicans.
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1) Li, Y., G. C. Unnithan, et al. (2003). “Stimulation of JH biosynthesis by the corpora allata of adult female Aedes aegypti in vitro: effect of farnesoic acid and Aedes allatotropin.” J Exp Biol 206(Pt 11): 1825-32.
2) Zhao, N., J. Guan, et al. (2007). “Molecular cloning and biochemical characterization of indole-3-acetic acid methyltransferase from poplar.” Phytochemistry 68(11): 1537.
3) Chung, S.-C., T.-I. Kim, et al. (2010). “Candida albicans PHO81 is required for the inhibition of hyphal development by farnesoic acid.” FEBS letters 584(22): 4639.
4) Kim, I. H., et al. (2017). “A mosquito hemolymph odorant-binding protein family member specifically binds juvenile hormone.” J. Biol. Chem. 292: 15329-15339.
5) Kai, Z.-p., et al. (2018). “A rapid quantitative assay for juvenile hormones and intermediates in the biosynthetic pathway using gas chromatography tandem mass spectrometry.” Journal of Chromatography A 1538: 67-74.
Keywords: (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienoic acid