Phosphatidylethanol (PEth) is formed primarily by transphosphatidylation of phosphatidylcholine (PC) by phosphlipase D. Most PEth (about 75%) is incorporated into erythrocyte membranes, and is one of the longest-lived circulating EtOH metabolite yet identified. 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanol-d5 (d5-POPEth) has a fully deuterated ethanol headgroup and can be used as a mass spectrometry standard.
-20 °C or below
Featured in Publications
1) Javors, M. A., et al. (2016). “Characterization of the Pharmacokinetics of Phosphatidylethanol 16:0/18:1 and 16:0/18:2 in Human Whole Blood After Alcohol Consumption in a Clinical Laboratory Study.” Alcohol Clin Exp Res 40(6): 1228-1234.
2) Thompson, P. M., et al. (2016). “Phosphatidylethanol in Postmortem Brain and Serum Ethanol at Time of Death.” Alcohol Clin Exp Res 40(12): 2557-2562.
3) McDonell, M. G., et al. (2017). “Pilot investigation of a phosphatidylethanol-based contingency management intervention targeting alcohol use.” Psychol Addict Behav 31(5): 608-613.
4) van der Nagel, B. C. H., et al. (2018). “Quantification of phosphatidylethanols in whole blood as a proxy for chronic alcohol consumption, using ultra performance convergence chromatography tandem mass spectrometry.” Ther Drug Monit 40(2): 268-275.