d5-D-myo-Phosphatidylinositol 4,5-bisphosphate DiC16

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4,5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in several tissues and is a substrate for class I phosphoinositide 3-kinase (PI3-K). This analog is deuterated at the glycerol.