GloPIPs BODIPY FL-PI(4,5)P2, C16

Product Number: C-45F16A

$418.00$696.00

$418.00
$696.00
SKU: C-45F16A- Category: Tags: , , , , ,

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4,5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PI(3,4,5)P3.


GloPIPs are labeled at the sn-1 position with BODIPY®-FL (505/513), BODIPY®-TMR (544/574), or biotin. The sn-1 linkage in these labeled PIPs has been changed to a more stable amide from an ester. Results from experiments conducted at Echelon indicated that this minor chemical change did not have a significant effect in any of the applications tested.

Excitation/Emission

503/513 nm

Storage

-20 °C, protect from light

Publications

1) Blin, G., E. Margeat, et al. (2008). “Quantitative analysis of the binding of ezrin to large unilamellar vesicles containing phosphatidylinositol 4,5 bisphosphate.” Biophys J 94(3): 1021-33.

Bulk discounts available, please email echelon@echelon-inc.com for information.

Categories

Lipids

Filter

Fluorescent, Phosphoinositides, PI(4,5)P2

Technical Data Sheet

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