GloPIPs BODIPY FL-PI(4,5)P2, C16

Product Number: C-45F16A

$484
$806

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4,5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PI(3,4,5)P3.


GloPIPs are labeled at the sn-1 position with BODIPY®-FL (505/513), BODIPY®-TMR (544/574), or biotin. The sn-1 linkage in these labeled PIPs has been changed to a more stable amide from an ester. Results from experiments conducted at Echelon indicated that this minor chemical change did not have a significant effect in any of the applications tested.

Bulk discounts available, please email echelon@echelon-inc.com for information.

Categories

Lipids

Filter

Fluorescent, Phosphoinositides, PI(4,5)P2

Excitation/Emission

503/513 nm

Molecular Formula

C63H121BF2N7O19P3

Molecular Weight (g/mol)

1422.4

Purity

>95%

Storage

-20 °C or below, protect from light

Shipping Temp

Dry ice or gel ice depending on destination

Technical Data Sheet

1) Blin, G., E. Margeat, et al. (2008). “Quantitative analysis of the binding of ezrin to large unilamellar vesicles containing phosphatidylinositol 4,5 bisphosphate.” Biophys J 94(3): 1021-33.

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