This product has been discontinued.
PtdIns(4,5)P2 a-fluorophosphonate diC8 (ms-PtdIns(4,5)P2 diC8) is a water soluble, synthetic PI(4,5)P2 analog in which the phosphodiester bond has been rendered metabolically stable via the α-fluorophosphonate. P-F4508 restores the TRPM4 ion channel current at 10μM.
Featured in Publications
1. Zhang, H., et al. (2016). “Synthesis and Biological Activity of Phospholipase C-Resistant Analogues of Phosphatidylinositol 4,5-bisphosphate”J. Am. Chem. Soc. 128(17): 5642-5643.