Molecular Weight: 543.32
Salt Form: TFA
Sequence (3-letter): D-Val-Leu-Arg-AMC
Sequence (1-letter): vLR-AMC
Storage: -20 °C or below
D-Val-Leu-Arg-AMC is a fluorogenic substrate for the serine protease glandular tissue kallikrein. Kallikrein is responsible for the regulation of blood pressure and activation of inflammation by releasing kinins (bradykinin and kallidin) from kinogens.
Activity is quantified by release of free fluorescent 7-amino-4-methylcoumarin (AMC) which excites at 360-380 nm and emits at 440-460 nm.