Molecular Weight: 1257.67
Salt Form: TFA
Sequence (3-letter): Asn-Arg-Val-Tyr-Val-His-Pro-Phe-Asn-Leu-OH
Sequence (1-letter): NRVYVHPFNL-OH
Storage: -20 °C or below
Angiotensin I, also known as proangiotensin is formed from angiotensinogen by the action of renin. Angiotensin I has no direct biological function but is a precursor to angiotensin II through cleavage of the two terminal amino acids by angiotensin converting enzyme (ACE). Angiotensin I [Asn1,Val5,Asn9], salmon and other peptides derived from aquatic animals may inhibit ACE making them attractive targets for development of blood pressure medications.
Cheung HS, Wang FL, Ondetti MA, Sabo EF, Cushman DW. (1980) Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. Importance of the COOH-terminal dipeptide sequence. J Biol Chem. Jan 25;255(2):401-7.