Cell Permeable Caspase 3 Inhibitor

Product Number: 864-29

$96
$184

Molecular Weight: 1999.1
Salt Form: N/A
Purity: >90%
Sequence (3-letter): Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Glu-Val-Asp-CHO
Sequence (1-letter): Ac-AAVALLPAVLLALLAPDEVD-CHO
Storage: -20 °C or below

A cell-permeable inhibitor with the potent, caspase 3 selective sequence DEVD-CHO at the C-terminus (Ki < 1 nM). It will also inhibit PARP cleavage in cultured human osteosarcoma cell extracts (IC50 = 200 pM). Cell permeability is conferred by the 16-residue N-terminal sequence  corresponding to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF) .

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-20 °C or below

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