Cardiolipin Grip

Product number: G-CL01

$50.00$400.00

$50.00
$150.00
$400.00

Cardiolipin Grip (G-CL01) is a recombinant N-terminal GST-tagged cardiolipin binding protein expressed in E. coli. Cardiolipin Grip recognizes multiple species of cardiolipin in a competitive ELISA format on cardiolipin coated plates.

Cardiolipin is an important component in prokaryotic and in eukaryotic inner mitochondrial membrane1. Autoantibodies to CL have been found in patients with anti-phospholipid syndrome and lupus2 and disruptions is CL remodeling have been associated with other diseases such as Barth’s syndrome.

Storage: -20 °C. Aliquot and freeze if intended for multiple uses. Protein will be stable for at least 6 months from date of shipment.


References

1) Schlame M, Horvath L, Vigh L. “Relationship between lipid saturation and lipid-protein interaction in liver mitochondria modified by catalytic hydrogenation with reference to cardiolipin molecular species.” Biochem J 1990;265:79-85.
2. McNeil HP, Simpson RJ, Chesterman CN, Krilis SA. “Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H).” Proc Natl Acad Sci U S A 1990;87:4120-4.
3.  Xu Y.; Malhotra A.; Ren M.; Schlame M. (2006). “The enzymatic function of tafazzin”. J. Biol. Chem. 281 (51): 39217–39224. 


Documents

Technical Data Sheet

We are in the process of migrating our technical data sheets (TDS) to this space. They can currently be found in the description section of the product pages. Thank you for your patience. For any technical questions, please contact us at echelon@echelon-inc.com

 

Categories

Antibodies & Proteins

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Cardiolipin, Lipid Binding

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