CAS Number: 17650-98-5
Molecular Weight: 1352.43
Salt Form: N/A
Sequence (3-letter): Glp-Gln-Asp-Tyr(SO3H)-Thr-Gly-Trp-Met-Asp-Phe-NH2 (Glp = Pyroglutamic acid)
Sequence (1-letter): (Glp)QD(Tyr(SO3H))TGWMDF-NH2
Storage: -20 °C or below
Solubility: water, >1 mg/mL
Caerulein is a sulfated peptide that is used in the study of NF-κB-mediated signaling. When administered via i.v., it can produce analgesia. It has also been shown to induce pancreatitis in animals at high doses and prevent pain associated with gall-bladder contraction and intermittent claudication.
1. Baber, N.S., Dourish, C.T. and Hill, D.R. (1989) “The role of CCK, caerulein, and CCK antagonists in nociception” Pain 9: 307-328.
2.Watanabe, O. et al (1984) “Supramaximal caerulein stimulation and ultrastructure of rat pancreatic acinar cell: early morphological changes during development of experimental pancreatitis” Am. J. Physiol. 246(4 Pt 1): G457-67.