C12-200

Product Number: N-1220

$110
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$380
$670

C12-200 is an ionizable lipid used to generate lipid nanoparticles (LNPs) for delivery of siRNA, mRNA, and saRNA in several cell types and animal models. C12-200 LNPs were able to safely deliver placental growth factor mRNA to the placenta in a pregnant mouse model.

Categories

Lipids

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Ionizable/Cationic Lipids

CAS Number

1220890-25-4

Molecular Formula

C70H145N5O5

Molecular Weight (g/mol)

1136.96

Purity

>90%

Storage

-20 °C or below

Shipping Temp

Ambient Temperature

Technical Data Sheet

1) Kevin T. Love et al; Lipid-like materials for low-dose in vivo gene silencing, PNAS, 2010, 107(5): 1864-1869.
2) Whitehead, K. A. et al. Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity. Nat. Commun. 2014, 5:4277, doi: 10.1038/ncomms5277.
3) Young RE, Nelson KM, et al. Systematic development of ionizable lipid nanoparticles for placental mRNA delivery using a design of experiments approach. Bioact Mater. 2023 Dec 22;34:125-137. doi: 10.1016/j.bioactmat.2023.11.014.

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