Autocamtide-2 Related Inhibitory Peptide, myristoylated

Product Number: 891-26


Molecular Weight: 1707.08
Salt Form: TFA
Purity: >96%
Sequence (3-letter): Myristoyl-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH
Sequence (1-letter): (Myristoyl)KKALRRQEAVDAL-OH
Storage: -20 °C or below

Autocamtide-2 Related Inhibitory Peptide is a calmodulin-dependent protein kinase II (CaMKII) inhibitor (IC50 = 40 nM) that contains the autophosphorylation site (Thr286/Thr287) found within the autoinhibitory domain of the protein kinase. It is nonphosphorylatable and selective for CaMKII over other protein kinases such as PKC and PKA and is not capable of being phosphorylated. This compound is a used to study the physiological roles of CaMKII. The myristoyl modification allows for cell permeability.


Ishida, A., Kameshita, I., Okuno, S., et al. (1995)A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II”. Biochemical and Biophysical Research Communications 212(3), 806-812





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