AS1949490 (SHIP2 Inhibitor)

Product Number: B-0342

$97
$179
$418

AS1949490 is a potent, selective SHIP2 inhibitor with IC50 of 0.62 uM for human, which shows less effect on SHIP1 or no effects on some other types of intracellular phosphatases (such as PTEN, synaptojanin, and myotubularin). This compound also activates intracellular insulin signaling pathways in the liver and displays gluconeogensis regulation and antidiabetic effects.

References

A. Suwa, T. Yamanoto, et al. “Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2”, British Journal of Pharmacology, 2009,158, 879-88.


Categories

Biochemical Reagents

Filter

Inhibitor, SHIP

CAS Number

1203680-76-5

Molecular Formula

C20H18ClNO2S

Molecular Weight (g/mol)

371.88

Purity

>95%

Storage

4 °C or below

Shipping Temp

Ambient Temperature

Technical Data Sheet

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