Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation, chemotaxis, platelet aggregation, wound healing, angiogenesis, tumor invasion, and smooth muscle contraction. LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer, LPA primarily promotes cell survival, migration and invasion. May contain up to 5-10% of the 2-acyl isomer due to acyl transfer.
| Molecular Weight (g/mol) | 480.51 |
|---|---|
| Molecular Formula | C23H38NaO7P |
| CAS Number | 799268-65-8 |
| Storage | -80 °C |
| Categories | Lipids |
| Filter | Lysophosphatidic Acid, Lysophospholipid |
1) Fujiwara, Y., et al. (2005). “Identification of residues responsible for ligand recognition and regioisomeric selectivity of LPA receptors expressed in mammalian cells.” J Biol Chem 280(41): 35038-35050.
2) Leslie, D. S., et al. (2008). “Serum lipids regulate dendritic cell CD1 expression and function.” Immunology 125(3): 289-301.
3) Saga, H., et al. (2014). “A Novel Highly Potent Autotaxin/ENPP2 Inhibitor Produces Prolonged Decreases in Plasma Lysophosphatidic Acid Formation <italic>In Vivo</italic> and Regulates Urethral Tension.” PLoS ONE 9(4): e93230.
4) Reinartz, S., et al. (2019). “Cell-type-selective pathways and clinical associations of lysophosphatidic acid biosynthesis and signaling in the ovarian cancer microenvironment.” Molecular Oncology 13(2): 185-201.
5) Ledein, L., et al. (2020). “Translational engagement of lysophosphatidic acid receptor 1 in skin fibrosis: from dermal fibroblasts of patients with scleroderma to tight skin 1 mouse.” British Journal of Pharmacology 177(18): 4296-4309.
You may also like…
Related products
-
-
-
Biochemical ReagentsLyosphosphatidic Acid (LPA) Beads
$147 – $689 View productsProduct Number: L-6101
-
Biochemical ReagentsKi16425 (LPA Receptor Antagonist)
$60 – $461 View productsProduct Number: B-0730