Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation, chemotaxis, platelet aggregation, wound healing, angiogenesis, tumor invasion, and smooth muscle contraction. LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer, LPA primarily promotes cell survival, migration and invasion. May contain up to 5-10% of the 2-acyl isomer due to acyl transfer.
|Molecular Weight (g/mol)||
Lysophosphatidic Acid, Lysophospholipid
1) Fujiwara, Y., et al. (2005). “Identification of residues responsible for ligand recognition and regioisomeric selectivity of LPA receptors expressed in mammalian cells.” J Biol Chem 280(41): 35038-35050.
2) Leslie, D. S., et al. (2008). “Serum lipids regulate dendritic cell CD1 expression and function.” Immunology 125(3): 289-301.
3) Saga, H., et al. (2014). “A Novel Highly Potent Autotaxin/ENPP2 Inhibitor Produces Prolonged Decreases in Plasma Lysophosphatidic Acid Formation <italic>In Vivo</italic> and Regulates Urethral Tension.” PLoS ONE 9(4): e93230.
4) Reinartz, S., et al. (2019). “Cell-type-selective pathways and clinical associations of lysophosphatidic acid biosynthesis and signaling in the ovarian cancer microenvironment.” Molecular Oncology 13(2): 185-201.
5) Ledein, L., et al. (2020). “Translational engagement of lysophosphatidic acid receptor 1 in skin fibrosis: from dermal fibroblasts of patients with scleroderma to tight skin 1 mouse.” British Journal of Pharmacology 177(18): 4296-4309.
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Kits & Assays
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