Arachidonoyl LPA, 20:4 LPA

Product Number: L-0204


Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation, chemotaxis, platelet aggregation, wound healing, angiogenesis, tumor invasion, and smooth muscle contraction. LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer, LPA primarily promotes cell survival, migration and invasion. May contain up to 5-10% of the 2-acyl isomer due to acyl transfer.

Molecular Weight (g/mol)


Molecular Formula


CAS Number



-80 °C




Lysophosphatidic Acid, Lysophospholipid

Shipping Temp

Gel Ice

Technical Data Sheet

1) Fujiwara, Y., et al. (2005). “Identification of residues responsible for ligand recognition and regioisomeric selectivity of LPA receptors expressed in mammalian cells.” J Biol Chem 280(41): 35038-35050.
2) Leslie, D. S., et al. (2008). “Serum lipids regulate dendritic cell CD1 expression and function.” Immunology 125(3): 289-301.
3) Saga, H., et al. (2014). “A Novel Highly Potent Autotaxin/ENPP2 Inhibitor Produces Prolonged Decreases in Plasma Lysophosphatidic Acid Formation <italic>In Vivo</italic> and Regulates Urethral Tension.” PLoS ONE 9(4): e93230.
4) Reinartz, S., et al. (2019). “Cell-type-selective pathways and clinical associations of lysophosphatidic acid biosynthesis and signaling in the ovarian cancer microenvironment.” Molecular Oncology 13(2): 185-201.
5) Ledein, L., et al. (2020). “Translational engagement of lysophosphatidic acid receptor 1 in skin fibrosis: from dermal fibroblasts of patients with scleroderma to tight skin 1 mouse.” British Journal of Pharmacology 177(18): 4296-4309.

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