Ac-Trp-Glu-His-Asp-AMC (Caspase 1 (ICE) Substrate)

Product Number: 860-60

$130.00$487.00

$130.00
$487.00
SKU: 860-60 Category: Tags: ,

CAS Number: 189275-74-9
Molecular Weight: 784.79
Salt Form: TFA
Purity: >96%
Sequence (3-letter): Ac-Trp-Glu-His-Asp-AMC
Sequence (1-letter): Ac-WEHD-AMC
Storage: -20 °C or below

Ac-Trp-Glu-His-Asp-AMC is a fluorogenic substrate for Caspase 1. Caspase 1/Interleukin 1b converting enzyme (ICE) is a cysteine protease that converts inactive IL-1 beta precursor to a pro-inflammatory cytokine that mediates a wide range of immune and inflammatory response. ICE-related cysteine proteases are required for E1A-induced, p53-dependent apoptosis in baby rat kidney (BRK) cells. Adenovirus E1B 19K protein, which is a potent inhibitor of apoptosis, inhibits activation of these proteases in BRK cells. Ac-WEHD-AMC is cleaved more efficiently than Ac-YVAD-AMC.

Activity is quantified by release of free fluorescent 7-amino-4-methylcoumarin (AMC) which excites at 360-380 nm and emits at 440-460 nm.

We are in the process of migrating our technical data sheets (TDS) to this space. They can currently be found in the description section of the product pages. Thank you for your patience. For any technical questions, please contact us at echelon@echelon-inc.com

 

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