CAS Number: 210345-02-1
Molecular Weight: 729.67
Salt Form: N/A
Sequence (3-letter): Ac-Leu-Glu-Thr-Asp-AFC
Sequence (1-letter): Ac-LETD-AFC
Storage: -20 °C or below
Ac-Leu-Glu-Thr-Asp-AFC is a fluorogenic substrate for caspase 8. Caspase 8 is a cysteine protease involved in apoptosis induced by Fas and other stimuli. It is an attractive therapeutic target for a variety of degenerative disorders.
Activity is quantified by release of free fluorescent 7-amino-4-trifluoromethylcoumarin (AFC) which excites at 395-400 nm and emits at 495-505 nm.