Ac-DEVD-CHO, Caspase 3 (Apopain) Inhibitor

Product Number: 864-20

$194.00

$194.00

CAS Number: 184179-08-6
Molecular Weight: 502.19
Salt Form: N/A
Purity: >95%
Sequence (3-letter): Ac-Asp-Glu-Val-Asp-CHO
Sequence (1-letter): Ac-DEVD-CHO
Storage: -20 °C or below
Solubility: 13.7 mg/ml in DMSO

Caspase-3 (Apopain) is commonly activated by numerous death signals and cleaves a variety of important cellular proteins and is essential for brain development. Ac-DEVD-CHO is a potent, reversible inhibitor of caspase-3 (Ki < 1nM for purified caspase-3) and also inhibits caspase-7 (Ki = 1.6 nM) as well as other caspases to a lesser extent.

References

1. Talanian, R.V. et al (1997) “Substrate Specificities of Caspase Family Proteases” 272 (15): 9677–9682.
2. Godinat, A. et al. (2013) “A Biocompatible in Vivo Ligation Reaction and Its Application for Noninvasive Bioluminescent Imaging of Protease Activity in Living Mice” ACS Chemical Biology 8 (5): 987-999.

We are in the process of migrating our technical data sheets (TDS) to this space. They can currently be found in the description section of the product pages. Thank you for your patience. For any technical questions, please contact us at echelon@echelon-inc.com

 

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