Ac-DEVD-CHO, Caspase 3 (Apopain) Inhibitor

Product Number: 864-20

$214

CAS Number: 184179-08-6
Molecular Weight: 502.19
Salt Form: N/A
Purity: >95%
Sequence (3-letter): Ac-Asp-Glu-Val-Asp-CHO
Sequence (1-letter): Ac-DEVD-CHO
Storage: -20 °C or below
Solubility: 13.7 mg/ml in DMSO

Caspase-3 (Apopain) is commonly activated by numerous death signals and cleaves a variety of important cellular proteins and is essential for brain development. Ac-DEVD-CHO is a potent, reversible inhibitor of caspase-3 (Ki < 1nM for purified caspase-3) and also inhibits caspase-7 (Ki = 1.6 nM) as well as other caspases to a lesser extent.

References

1. Talanian, R.V. et al (1997) “Substrate Specificities of Caspase Family Proteases” 272 (15): 9677–9682.
2. Godinat, A. et al. (2013) “A Biocompatible in Vivo Ligation Reaction and Its Application for Noninvasive Bioluminescent Imaging of Protease Activity in Living Mice” ACS Chemical Biology 8 (5): 987-999.

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Caspase, Inhibitor

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-20 °C or below

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