5-Ketoclomazone inhibits 1-deoxy-D-xylulose 5-phosphate (DXP) synthase, the first enzyme of the MEP pathway (non-mevalonate pathway) of isoprenoid biosynthesis.
1) Y. Matsue, H. Mizuno, T. Tomita, et al. “The herbicide ketoclomazone inhibits 1-deoxy-D-xylulose 5-phosphate synthase in the 2-C-methyl-D-erythritol 4-phosphate pathway and shows antibacterial activity against Haemophilus influenzae” J. Antibiotics (2010), 63, 583-588. DOI: 10.1038/ja.2010.100