ATX-Red AR-2

Product Number: L-2010

$106.05$812.70

$106.05
$514.50
$812.70

ATX-Red AR-2 is an in vivo imaging probe for visualizing and measuring ATX activity. It is an analog of the autotaxin substrate lysophosphatidylcholine (LPC) and contains a near-infrared fluor (Licor IRDye® 800CW) and quencher (Licor IRDye® QC-1). The design is modeled after FS-3, a fluorogenic ATX substrate that is predictive of ATX activity. In the parent compound, fluorescence is quenched through intramolecular energy transfer, but when autotaxin cleaves ATX-Red AR-2, fluorescence increases. This activation mechanism is specific to autotaxin in vitro and in vivo.


Autotaxin which has lysophospholipase D (lysoPLD) activity, cleaves choline from lysophosphatidylcholine forming lysophosphatidic acid (LPA), a potent mitogen that as been implicated in the pathophysiology of ovarian cancer. LysoPLD/ATX has been demonstrated to increase cell motility, neovascularization, proliferation, and aggressiveness of tumors and is upregulated in numerous cancer lineages (non-small cell lung , glioma, mammary carcinoma, renal cell carcinoma, hepatocellular carcinoma). In addition, dysregulation of the ATX/LPA pathway is central to the pathophysiology of idiopathic pulmonary fibrosis, rheumatoid arthritis, and other inflammatory diseases. Modulation of ATX activity through small-molecules is a currently underexplored target, but one with high potential for novel cancer and anti-inflammatory therapeutics.

Notice to Purchaser: Echelon Biosciences products are sold for research and development purposes only and are not to be incorporated into products for resale without written permission from Echelon Biosciences. The compound AR-2 and its use in assaying for Lysophospholipase D activity are covered by Echelon Biosciences Inc. US patents 7,485,259 & 7,989,663. The purchase of this product includes a limited, non-transferable immunity from suit under the foregoing patent claims for using only this amount of product for the purchaser’s own internal research. For inquiries email busdev@echelon-inc.com

Bulk discounts available, please email echelon@echelon-inc.com for information.

Categories

Biochemical Reagents

Filter

Autotaxin, Fluorescent

Excitation/Emission

775/800 nm

Molecular Formula

C159H263ClN15O39PS8

Molecular Weight (g/mol)

3331.81

Purity

>90%

Storage

-20 °C or below, protect from light

Technical Data Sheet

1) Madan, D., C.G. Ferguson, et al. (2013) “Non-Invasive Imaging of Tumors by Monitoring Autotaxin Activity Using an Enzyme-Activated Near-Infrared Fluorogenic Substrate” PLoS One 8(11): e79065
2) Rais, B., et al. (2015). Animal Test Models for Implant-Associated Inflammation and Infections. Biomedical Technology. T. Lenarz and P. Wriggers. Cham, Springer International Publishing:175-187.
3) Reich, R., et al. (2015). “Carbamoylphosphonates inhibit autotaxin and metastasis formation in vivo.” J Enzyme Inhib Med Chem 30(5): 767-772.

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