4A3-SC8 is an ionizable lipid dendrimer used in generating lipid nanoparticles (LNPs) for RNA delivery. Incorporation of differently charged lipids (DODAP, DOTAP, or PA) into 4A3-SC8 LNPs allow for selective delivery of RNA to the liver, lungs, or spleen.
| Categories | Lipids |
|---|---|
| Filter | Ionizable/Cationic Lipids |
| CAS Number | 1857340-78-3 |
| Molecular Formula | C75H139N3O16S4 |
| Molecular Weight (g/mol) | 1467.18 |
| Purity | >95% |
| Storage | -20 °C or below |
1) Wang, X., Liu, S., Sun, Y. et al. Preparation of selective organ-targeting (SORT) lipid nanoparticles (LNPs) using multiple technical methods for tissue-specific mRNA delivery. Nat Protoc 18, 265–291 (2023). https://doi.org/10.1038/s41596-022-00755-x
2) Cheng, Q., Wei, T., Farbiak, L. et al. Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing. Nat. Nanotechnol. 15, 313–320 (2020). https://doi.org/10.1038/s41565-020-0669-6
3) Wei, T., Cheng, Q., Min, YL. et al. Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing. Nat Commun 11, 3232 (2020). https://doi.org/10.1038/s41467-020-17029-3
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