L-3223 (GWJ-23 or GWJ-A-23) is a potent inhibitor of the enzyme autotaxin (Ki = 18 nM). It is an analog of the known ATX inhibitor S32826 and has improved aqueous solubility compared with the parent compound. GWJ-A-23 has been shown to reduce lung collagen, bronchoalveolar lavage cell counts, total protein, LPA, and TGF-β levels in an idiopathic pulmonary fibrosis mouse model (Ref. 2).
-20°C or below.
1) Tager, A.M. (2012) “Autotaxin Emerges as a Therapeutic Target for Idiopathic Pulmonary Fibrosis: Limiting Fibrosis by Limiting Lysophosphatidic Acid Synthesis” Am. J. Resp. Cell Mol. Biol. 47(5): 563-565.
2) Oikonomou, N, M.A. Mouratis, et al. (2012) “Pulmonary Autotaxin Expression Contributes to the Pathogenesis of Pulmonary Fibrosis.” Am. J. Resp. Cell Mol. Biol. 47(5): 566-574.
3) Jiang, G., D. Madan, et al. (2011). “Aromatic phosphonates inhibit the lysophospholipase D activity of autotaxin.” Bioorganic & Medicinal Chemistry Letters 21(17): 5098.