[4-(Decanoylamino)benzyl] phosphonic acid (GWJ-23, GWJ-A-23)

Product Number: L-3223

$41.00$325.00

$41.00
$183.00
$325.00
SKU: L-3223- Category: Tags: , ,

L-3223 (GWJ-23 or GWJ-A-23) is a potent inhibitor of the enzyme autotaxin (Ki = 18 nM). It is an analog of the known ATX inhibitor S32826 and has improved aqueous solubility compared with the parent compound. GWJ-A-23 has been shown to reduce lung collagen, bronchoalveolar lavage cell counts, total protein, LPA, and TGF-β levels in an idiopathic pulmonary fibrosis mouse model (Ref. 2).


Storage

-20°C or below.

Publications

1) Tager, A.M. (2012) “Autotaxin Emerges as a Therapeutic Target for Idiopathic Pulmonary Fibrosis: Limiting Fibrosis by Limiting Lysophosphatidic Acid Synthesis” Am. J. Resp. Cell Mol. Biol. 47(5): 563-565.
2) Oikonomou, N, M.A. Mouratis, et al. (2012) “Pulmonary Autotaxin Expression Contributes to the Pathogenesis of Pulmonary Fibrosis.” Am. J. Resp. Cell Mol. Biol. 47(5): 566-574.
3) Jiang, G., D. Madan, et al. (2011). “Aromatic phosphonates inhibit the lysophospholipase D activity of autotaxin.” Bioorganic & Medicinal Chemistry Letters 21(17): 5098.


Categories

Biochemical Reagents

Filter

Autotaxin, Inhibitor

CAS Number

1351930-95-4

Molecular Formula

C17H26NNa2O4P

Molecular Weight (g/mol)

385.14

Purity

>95%

Storage

-20 °C or below

Technical Data Sheet

You may also like…

  • FS-3 (LysoPLD / Autotaxin fluorogenic substrate) - Echelon Biosciences
    Biochemical Reagents

    FS-3 (LysoPLD / Autotaxin substrate)

    Product Number: L-2000

    $313.00$2,529.00 View products
  • HA130 (Autotaxin Inhibitor) - Echelon Biosciences
    Biochemical Reagents

    HA130 (Autotaxin Inhibitor)

    Product Number: B-0701

    $58.00$109.00 View products
  • Antibodies & Proteins

    Autotaxin Enzyme, active

    Product Number: E-4000

    $96.00$454.00 View products
  • PF-8380, ATX Inhibitor - Echelon Biosciences
    Biochemical Reagents

    PF-8380 (Autotaxin Inhibitor)

    Product Number: B-0702

    $47.00$169.00 View products
Scroll to Top