[4-(Decanoylamino)benzyl] phosphonic acid (GWJ-23, GWJ-A-23)

Product Number: L-3223

$40.00$311.00

$40.00
$175.00
$311.00
SKU: L-3223- Category: Tags: , ,

L-3223 (GWJ-23 or GWJ-A-23) is a potent inhibitor of the enzyme autotaxin (Ki = 18 nM). It is an analog of the known ATX inhibitor S32826 and has improved aqueous solubility compared with the parent compound. GWJ-A-23 has been shown to reduce lung collagen, bronchoalveolar lavage cell counts, total protein, LPA, and TGF-β levels in an idiopathic pulmonary fibrosis mouse model (Ref. 2).


Storage

-20°C or below.

Publications

1) Tager, A.M. (2012) “Autotaxin Emerges as a Therapeutic Target for Idiopathic Pulmonary Fibrosis: Limiting Fibrosis by Limiting Lysophosphatidic Acid Synthesis” Am. J. Resp. Cell Mol. Biol. 47(5): 563-565.
2) Oikonomou, N, M.A. Mouratis, et al. (2012) “Pulmonary Autotaxin Expression Contributes to the Pathogenesis of Pulmonary Fibrosis.” Am. J. Resp. Cell Mol. Biol. 47(5): 566-574.
3) Jiang, G., D. Madan, et al. (2011). “Aromatic phosphonates inhibit the lysophospholipase D activity of autotaxin.” Bioorganic & Medicinal Chemistry Letters 21(17): 5098.


Documents

Technical Data Sheet

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Categories

Biochemical Reagents

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Autotaxin, Inhibitor

CAS Number

1351930-95-4

Molecular Formula

C17H26NNa2O4P

Molecular Weight (g/mol)

385.14

Purity

>95%

Storage

-20 °C or below

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