306Oi10 is a biodegradable, branched chain lipidoid developed for RNA delivery in lipid nanoparticles (LNPs). Interestingly, the unbranched analog was 10-fold less effective in delivering luciferase mRNA in mice. The increased potency is thought to be due to increased cone-shaped structure and protonation at endosomal pH resulting in enhanced endosomal escape. 306Oi10 has been used to co-deliver three mRNAs (firefly luciferase, mCherry, and erythropoietin). The LNPs derived from 306Oi10 were not immunogenic or toxic to the liver.
306Oi10
N-1010
$47.00 – $368.00
| Categories | Lipids |
|---|---|
| Filter | Ionizable/Cationic Lipids |
| CAS Number | 2322290-93-5 |
| Molecular Formula | C59H115N3O8 |
| Molecular Weight (g/mol) | 994.58 |
| Purity | 95% |
| Storage | -20 °C or below |
1) Hajj KA, Ball RL, Deluty SB, Singh SR, Strelkova D, Knapp CM, Whitehead KA. (2019) “Branched-Tail Lipid Nanoparticles Potently Deliver mRNA In Vivo due to Enhanced Ionization at Endosomal pH.” Small. Feb;15(6):e1805097. doi: 10.1002/smll.201805097
2) Hajj KA, Melamed JR, Chaudhary N, Lamson NG, Ball RL, Yerneni SS, Whitehead, KA (2020) “A Potent Branched-Tail Lipid Nanoparticle Enables Multiplexed mRNA Delivery and Gene Editing In Vivo.” Nano Lett. 20, 5167−5175.
You may also like…
Related products
-
Biochemical ReagentsLyosphosphatidic Acid (LPA) Beads
$147.00 – $688.80 View productsProduct Number: L-6101
-
-
-
