DOTAP forms stable cationic liposomes in solution and can be used in the cell transfection of DNA, RNA, oligonucleotides, anionic proteins and small peptides.
| Categories | Lipids |
|---|---|
| Filter | Ionizable/Cationic Lipids |
| CAS Number | 132172-61-3 |
| Molecular Formula | C42H80NO4 • Cl |
| Molecular Weight (g/mol) | 698.54 |
| Purity | >95% |
| Storage | -20 °C or below |
1) Simberg D. et al (2004). “DOTAP (and Other Cationic Lipids): Chemistry, Biophysics, and Transfection”. Critical Reviews in Therapeutic Drug Carrier Systems. 21 (4): 257–317. DOI: 10.1615/critrevtherdrugcarriersyst.v21.i4.10.
2) Hou X. et al (2021). “Lipid nanoparticles for mRNA delivery“. Nat Rev Mater 6, 1078–1094. https://doi.org/10.1038/s41578-021-00358-0
