1-Naphthalenesulfonyl-Ile-Trp-CHO (Cathepsin L Inhibitor)

Product Number: 866-76

$144
$475

CAS Number: 161709-56-4
Molecular Weight: 491.2
Salt Form: N/A
Purity: >95%
Sequence (3-letter): 1-Naphthalenesulfonyl-Ile-Trp-CHO
Sequence (1-letter): (1-Naphthalenesulfonyl)IW-CHO
Storage: -20 °C or below

1-Naphthalenesulfonyl-Ile-Trp-aldehyde is a a reversible inhibitor of Cathepsin L (IC50 = 1.9 nM). Cathepsin L is a lysosomal cysteine protease with an important role in initiating protein degradation. Cathepsin L is also upregulated in several cancers and has been suggested as a drug target. In addition,  extracellular secretion of Cathepsin L by tumors implicates it as a potential serum biomarker for  cancer progression. In an in vitro bone culture system it inhibits the release of hydroxyproline and Ca2+ and prevents bone loss in ovariectomized mice (~50 mg/kg).

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