Autotaxin (ATX) Inhibitor Screening Service

 The Autotaxin (ATX) Inhibitor Screening Service utilizes the ATX Inhibitor Screening kits (cat #’s K-4200 or K-4200HTS) to determine if your compound inhibits ATX. ATX is an extracellular enzyme that cleaves lysophosphatidylcholine (LPC) to generate the phospholipid growth factor lysophophatidic acid (LPA). LPA is involved in a variety of biological functions, such as angiogenesis, wound healing, vascular and nervous system development, reproduction, pain transmission, immunological competence and the regulation of blood pressure. Altered LPA biology is associated with a number of diseases. Likewise, autotaxin has been implicated in a number of disorders, including a variety of cancers, obesity, arthritis, multiple sclerosis, Alzheimer’s disease and neuropathic pain.

  • Echelon has 25 years of assay development expertise and 15 years experience in the ATX field.
  • Your compounds are cataloged and stored according to your requirements.
  • The ATX inhibitor Screening Service will run each compound in duplicate, in two screens.
  • Results are provided as % inhibition or IC50, if a full inhibitor curve is ran.
  • Usually, results are provided 2 weeks from receipt of samples. We can accommodate tighter schedules if needed.

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Citations listed are from the Autotaxin Inhibitor Screening Kit (catalog number K-4200).

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