Z-Val-Phe-CHO (Calpain Inhibitor III)

Product Number: 870-50


CAS Number: 88191-84-8
Molecular Weight: 382.46
Salt Form: N/A
Purity: >96%
Sequence (3-letter): Z-Val-Phe-CHO, Z-Val-Phe-H
Sequence (1-letter): Z-VF-CHO
Storage: -20 °C or below
Solubility: DMSO to 25 mg/mL

Calpain Inhibitor III is a potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM) in addition to cathepsin B (Ki = 24 nM). Calpains are calcium-dependent cysteine proteases involved in a wide range of physiological processes. Calpain inhibitors can protect against necrotic neuronal death and, to a lesser extent, apoptotic death. Calpain inhibitors are useful tools for studying diseases, especially those involving neurodegeneration. Calpain Inhibitor III has been shown to inhibit neurofilament degradation in neurodegenerative diseases.


1.Wang, K.K. et al. (1996) “An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable Calpain inhibitor and is neuroprotective” Proc. Natl. Acad. Sci. USA 93 (13): 6687-6692
2.Wang, K.K. (2000) “Calpain and caspase: can you tell the difference?” Trends Neurosci. 23 (1): 20-26
3.Kunz, S et al. (2004) “The calpain inhibitor MDL 28170 prevents inflammation-induced neurofilament light chain breakdown in the spinal cord and reduces thermal hyperalgesia” Pain 110 (1-2): 409-18.





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