Z-Leu-Leu-Glu-AMC (Proteasome Substrate 2, fluorogenic)

CAS Number: 348086-66-8
Molecular Weight: 664.76
Salt Form: N/A
Purity: >96%
Sequence (3-letter): Z-Leu-Leu-Glu-AMC
Sequence (1-letter): Z-LLE-AMC
Storage: -20 °C or below

Z-Leu-Leu-Glu-AMC is a fluorogenic substrate for the caspase-like activity of the proteasome. The activity may be stimulated in the presence of Mg2+ ions and rapidly inactivated by N-acetylimidazole.

Activity is quantified by release of free fluorescent 7-amino-4-methylcoumarin (AMC) which excites at 360-380 nm and emits at 440-460 nm.