Z-Ile-Glu-Thr-Asp-AFC (Granzyme B Substrate)

Product Number: 863-56

$166
$632

CAS Number: 219138-02-0
Molecular Weight: 821.76
Salt Form: N/A
Purity: >96%
Sequence (3-letter): Z-Ile-Glu-Thr-Asp-AFC
Sequence (1-letter): Z-IETD-AFC
Storage: -20 °C or below

Z-IETD-AFC is a fluorogenic substrate for Granzyme B. Granzyme B is a serine protease found in cytotoxic T-cells and NK cells. It cleaves and activates several caspases involved in apoptosis.

Activity is quantified by release of free fluorescent 7-amino-4-trifluoromethylcoumarin (AFC) which excites at 395-400 nm and emits at 495-505 nm.

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Peptides

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Caspase, Enzyme Substrates

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Ambient Temperature

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-20 °C or below

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