Z-Gly-Gly-Arg-AMC (Urokinase Substrate III)

CAS Number: 102601-58-1
Molecular Weight: 579.24
Salt Form: HCl
Purity: >96%
Sequence (3-letter): Z-Gly-Gly-Arg-AMC, Cbz-Gly-Gly-Arg-AMC
Sequence (1-letter): Z-GGR-AMC, Cbz-GGR-AMC
Storage: -20 °C or below

Z-Gly-Gly-Arg-AMC is a fluorogenic substrate for urokinase. It will also act as a substrate for trypsin, thrombin, and tissue-type plasminogen.

Activity is quantified by release of free fluorescent 7-amino-4-methylcoumarin (AMC) which excites at 360-380 nm and emits at 440-460 nm.

Featured in Publication:

Y-J, Sun, G Valez, et al. “TMPRSS2 structure-phylogeny repositions Avoralstat for SARS-1 CoV-2 prophylaxis in mice” bioRxiv preprint, doi: https://doi.org/10.1101/2021.01.04.425289